Adenosine Receptors and Parkinson's Disease by Hiroshi Kase
By Hiroshi Kase
This e-book is the 1st definitive evaluate on adenosine receptor antagonists and their program to the remedy of Parkinson's ailment. The impression of those novel non-dopamine medicines on vitro and in vivo structures truly exhibits their strength for the remedy of this debilitating disorder. This publication covers how the Parkinson's affliction antagonist drug, A2A, has been researched, built, and proven. it's a vital ebook for researchers drawn to the basal ganglia, purine biology, and Parkinson's affliction. Key beneficial properties* Discusses the invention and improvement of a singular non-dopaminomimetic agent for Parkinson's affliction* offers the 1st definitive evaluate of adenosine antagonists and their function within the therapy of Parkinson's sickness* provides a brand new mechanism of motion of adenosine A2A receptor antagonists in motor functionProposes a speculation of adenosine A2A receptor functionality within the striatum* finished review of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, body structure, pharmacology, and neurochemistry viewpoints
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This e-book is the 1st definitive evaluate on adenosine receptor antagonists and their program to the remedy of Parkinson's affliction. The influence of those novel non-dopamine medicines on vitro and in vivo platforms sincerely exhibits their capability for the therapy of this debilitating illness. This publication covers how the Parkinson's illness antagonist drug, A2A, has been researched, built, and proven.
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Extra resources for Adenosine Receptors and Parkinson's Disease
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1994). , 1989). 34 TABLE I J. 7 e 17f aInhibition of radioligand binding to hInhibition of radioligand binding to CInhibition of binding to membranes aInhibition of binding to membranes eInhibition of binding membranes human adenosine receptors. fICs0 value. , 1995 membranes from rat brain, otherwise noted. membranes from rat striatum, otherwise noted. from rhesus monkey cortex. from rhesus monkey striatum. from HEK-293 cells stably transfected with recombinant The most intensively investigated class of adenosine A 1 antagonists besides the xanthines are adenine derivatives.
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