Organic Chemistry

The Power of Functional Resins in Organic Synthesis by Fernando Albericio, Judit Tulla-Puche

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By Fernando Albericio, Judit Tulla-Puche

Whereas many books conceal good part synthesis and combinatorial synthesis, this one is exclusive in its particular insurance of the opposite points of solid-phase synthesis. As such, it comprises every little thing you want to comprehend -- from supported reagents, to scavengers, resins, and the synthesis of biomolecules and typical products.
a useful better half for all chemists and biochemists operating in collage examine and undefined.

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47 Renil, M. and Meldal, M. (1996) Tetrahedron Letters, 37, 6185–8. 48 Buchardt, J. and Meldal, M. (1998) Tetrahedron Letters, 38, 8695–8. , Meldal, M. and Bock, K. (1999) Chemistry – A European Journal, 5, 1088–95. , Meldal, M. and Bock, K. (1999) Proceedings of the 25th European Peptide Symposium (eds S. Bajusz and F. Hudecz), Akadémiai Kiadó, Budapest, pp. 38–9. , Meldal, M. and Bock, K. (1999) Journal of the American Chemical Society, 121, 5459–66. 52 Côté, S. (2005) PCT Int. Appl. WO 2005012277.

A popular strategy has been to imprint a transition state analog to obtain a polymer that reduces the activation energy of the reaction. Catalytically active groups are often included in the polymer network. This approach has been applied towards ester and amide hydrolysis reactions [245, 246]. Examples of other reactions where MIPs have been utilized as enzyme mimics are isomerization [247], transamination [248], Diels–Alder reaction [249], β-elimination [250] and regioselective cycloaddition [251].

1998) Biotechnology and Bioengineering, 61, 77–9. 15 Hudson, D. (1999) Journal of Combinatorial Chemistry, 1, 333–60. 16 Van den Nest, W. and Albericio, F. (2001) Optimization of Solid-Phase Combinatorial Synthesis (eds B. W. Czarnik), Marcel Dekker, New York, pp. 91–107. , Orain, D. and Bradley, M. (2000) Chemical Reviews, 100, 2091– 157. , et al. (1990) Journal of Organic Chemistry, 55, 3730–43. , et al. (2004) QSAR and Combinatorial Science, 23, 145–52. , et al. (2007) Organic Letters, 9, 4319–22.

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