Basic Science

microRNA: Medical Evidence: From Molecular Biology to by Gaetano Santulli

Posted On February 25, 2017 at 2:46 pm by / Comments Off on microRNA: Medical Evidence: From Molecular Biology to by Gaetano Santulli

By Gaetano Santulli

This quantity explores microRNA functionality in a big selection of human issues, supplying a medical foundation for precision drugs and customized remedies utilizing those molecules. The twenty-one chapters, all authored through internationally-renowned specialists, open with an creation contextualizing microRNA manipulation inside today’s tasks in the direction of precision drugs. the next chapters discover the medical position of microRNAs within the analysis and therapy of metabolic and cardiovascular problems, targeting mitochondrial health, arterial high blood pressure, cardiovascular home improvement, cerebrovascular affliction, pulmonary high blood pressure, diabetic kidney sickness, and kidney transplantation. the following chapters speak about the significance of microRNAs within the wound therapeutic strategy and in epidermis affliction, within the pathogenesis of hypersensitivity, in human ovulation, and in an infection. The booklet concludes with chapters which define the rising function of microRNAS in doping and element microRNA profiling.

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2013;435:176–81. 61. Zhou S, Zhang S, Wang Y, Yi S, Zhao L, Tang X, Yu B, Gu X, Ding F. miR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury. Neurosci Lett. 2015;586:43–9. 62. Mullenbrock S, Shah J, Cooper GM. Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogenactivated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation.

26. Staaf S, Oerther S, Lucas G, Mattsson JP, Ernfors P. Differential regulation of TRP channels in a rat model of neuropathic pain. Pain. 2009;144:187–99. 27. Kynast KL, Russe OQ, Möser CV, Geisslinger G, Niederberger E. Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice. Pain. 2013;154:368–76. 28. Géranton SM, Fratto V, Tochiki KK, Hunt SP. Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn.

2011;2011:713435. 75. Li H, Huang Y, Ma C, Yu X, Zhang Z, Shen L. MiR-203 involves in neuropathic pain development and represses Rap1a expression in nerve growth factor differentiated neuronal PC12 cells. Clin J Pain. 2015;31:36–43. 76. Stornetta RL, Zhu JJ. Ras and Rap signaling in synaptic plasticity and mental disorders. Neuroscientist. 2011;17:54–78. 77. Urayama O, Murakoshi T, Kubota M, Hara Y, Chihara J, Ikawa Y. Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation.

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