Basic Science

Human Mitochondrial DNA and the Evolution of Homo sapiens by Hans-Jürgen Bandelt, Martin Richards, Vincent Macaulay

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By Hans-Jürgen Bandelt, Martin Richards, Vincent Macaulay

Mitochondrial DNA is among the such a lot heavily explored genetic platforms, since it can let us know a lot in regards to the human previous. This ebook takes a special standpoint, providing the disparate strands that needs to be tied jointly to take advantage of the program. From molecular biology to anthropology, data to historic DNA, this primary quantity of 3 offers a entire international photograph and a serious appraisal of human mitochondrial DNA edition.

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Extra resources for Human Mitochondrial DNA and the Evolution of Homo sapiens (Nucleic Acids and Molecular Biology, 18)

Sample text

In non-dividing tissues (muscle and neurons), relaxed replication may prevent the accumulation of deleterious somatic mutations that will be lost through random intracellular drift (Elson et al. 2001b). However, the same mechanism may also lead to very high levels of somatic mutations within individual cells (so-called clonal expansion) (Elson et al. 2001b). These cells accumulate throughout life (Brierley et al. 1998; Elson et al. 2001b), and the acquired mitochondrial deficiency may contribute to the human aging process (Wallace et al.

Nat Biotechnol 15:855–858 Bandelt H-J (2005) Mosaics of ancient mitochondrial DNA: positive indicators of nonauthenticity. Eur J Hum Genet 13:1106–1112 Bandelt H-J, Kong Q-P, Parson W, Salas A (2005) More evidence for non-maternal inheritance of mitochondrial DNA? J Med Genet 42:957–960 Bandelt H-J, Quintana-Murci L, Salas A, Macaulay V (2002) The fingerprint of phantom mutations in mitochondrial DNA data. Am J Hum Genet 71:1150–1160 Bensasson D, Feldman MW, Petrov DA (2003) Rates of DNA duplication and mitochondrial DNA insertion in the human genome.

Hum Mutat 25:207–221 Coller HA, Khrapko K, Herrero-Jimenez P, Vatland JA, Li-Sucholeiki X-C, Thilly WG (2005) Clustering of mutant mitochondrial DNA copies suggests stem cells are common in human bronchial epithelium. Mutat Res 578:256-271 Collura RV, Stewart C-B (1995) Insertions and duplications of mtDNA in the nuclear genomes of Old World monkeys and hominoids. Nature 378:485–489 Cooper A, Rambaut A, Macaulay V, Willerslev E, Hansen AJ, Stringer C (2001) Human origins and ancient human DNA. Science 292:1655–1656 Davis RE, Miller S, Herrnstadt C, Ghosh SS, Fahy E, Shinobu LA, Galasko D, Thal LJ, Beal MF, Howell N, Parker WD Jr (1997) Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease.

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