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Cannabinoids [Handbook of Experimental Pharmacology 168] by Roger G. Pertwee (Ed.), Roger G. Pertwee

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By Roger G. Pertwee (Ed.), Roger G. Pertwee

The current e-book is a phenomenal precis of many facets of cannabinoid study. It offers present wisdom concerning the pharmacology and healing capability of cannabinoids in addition to wisdom in regards to the pharmacology, body structure, and pathology of the endogenous cannabinoid platforms. The chapters are written through scientists who've made or are nonetheless making significant contributions to the sector. This publication may perhaps aid generate novel principles on easy methods to technique the research of emotions.

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Another compound that seems to be a neutral CB1 antagonist is VCHSR (Fig. 11). This is an analogue of SR141716A that lacks hydrogen bonding capability in its C3 substituent region and has a CB1 K i value in the low nanomolar range. VCHSR (1 µM) has been found to share the ability of SR141716A to attenuate R-(+)-WIN55212-induced inhibition of Ca2+ current in rat superior cervical ganglion neurons expressing the human CB1 receptor but to differ from SR141716A in not affecting Ca2+ current in these neurons when administered by itself at 1 or 10 µM (Hurst et al.

2001; Paton et al. 1998). This would suggest that unlike anandamide, these two agonists interact preferentially with CB1 receptors in this experimental model. There is evidence that anandamide and/or capsaicin can modulate glutamatergic transmission in brain areas other than the hippocampus in a manner that is CB1 -independent and susceptible to antagonism by capsazepine and/or iodoresiniferatoxin. These brain areas include rat locus coeruleus, substantia nigra and medullary dorsal horn (Jennings et al.

Br J Pharmacol 137:589–596 Bayewitch M, Rhee M-H, Avidor-Reiss T, Breuer A, Mechoulam R, Vogel Z (1996) (–)∆9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase. G. Pertwee Begg M, Mo F-M, Offertáler L, Bátkai S, Pacher P, Razdan RK, Lovinger DM, Kunos G (2003) G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. J Biol Chem 278:46188–46194 Ben-Shabat S, Fride E, Sheskin T, Tamiri T, Rhee M-H, Vogel Z, Bisogno T, De Petrocellis L, Di Marzo V, Mechoulam R (1998) An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity.

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