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Antiviral Drug Strategies (Methods and Principles in by Erik De Clercq

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By Erik De Clercq

Through concentrating on normal molecular mechanisms of antiviral medications instead of cures for person viruses, this prepared reference offers the serious wisdom had to improve completely novel therapeutics and to focus on new viruses.It starts off with a common dialogue of antiviral techniques, via a wide survey of recognized viral ambitions, comparable to opposite transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, in addition to their identified inhibitors. the ultimate part includes a number of instances experiences of contemporary profitable antiviral drug development.Edited by way of Erik de Clercq, the area authority on small molecule antiviral medications, who has built extra new antivirals than an individual else.

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Additional info for Antiviral Drug Strategies (Methods and Principles in Medicinal Chemistry, Volume 50)

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And Holy, A. (2005) Acyclic nucleoside phosphonates: a key class of antiviral drugs. Nature Reviews Drug Discovery, 4, 928–940. De Clercq, E. (2009) Another ten stories in antiviral drug discovery (partC): “old” and “new” antivirals, strategies, and perspectives. Medicinal Research Reviews, 29, 611–645. De Clercq, E. (2004) Non-nucleoside reverse transcriptase inhibitors (NNRTIs): past, present and future. Chemistry Biodiversity, 1, 44–64. , and Arnold, E. (1995) Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors.

However, the core domains of gp120 are truncated versions of the envelope glycoprotein. The crystallized gp120 derivatives have been deglycosylated and they lacked 52 N-terminal and 19 C-terminal residues and 67 residues forming the V1/V2 loop and 32 residues of the V3 loop. In addition, all sugar groups beyond the linkages between the two core N-acetylglucosamine residues were removed. Unfortunately, the gp120 crystal structures lack the V3 loop, and assumptions on its real conformation have to rely on data obtained from crystal structures of V3 peptide–antibody complexes and the existing data on the cross-reactivity of antibodies.

De Clercq, E. (2006) Antiviral agents active against influenza A viruses. Nature Reviews Drug Discovery, 5, 1015–1025. , and Shiraki, K. (2005) Mechanism of action of T-705 against influenza virus. Antimicrobial Agents and Chemotherapy, 49, 981–986. De Clercq, E. (2010) Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes and paraductions. Medicinal Research Reviews, 30 (4), 667–707. D. (2004) In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms.

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