Advances in Synthetic Organic Chemistry and Methods Reported by Thomas F. DeRosa
By Thomas F. DeRosa
Advances in artificial natural Chemistry and strategies mentioned in US Patents offers man made instructions for getting ready present and commercially major natural compounds, derivatives, and intermediates as suggested in issued US Patents. Industries surveyed contain agrochemical, cosmetics and private care items. each one access includes huge details corresponding to specific laboratory instructions for getting ready all chemical intermediates and characterization facts. in addition, product optimization reports, commercial training, and new man made tools were incorporated for chosen entries, in addition to projected study instructions for destiny product improvement. In Advances in man made natural Chemistry and techniques said in US Patents the author's functional technique permits readers to spot learn and industry tendencies, and remain updated on present advancements within the box. * presents man made instructions for getting ready present and commercially major natural compounds, derivatives, and intermediates as pronounced in issued US Patents * Identifies product improvement developments to aid make certain study parts * Elucidates use of the USA Patent and Trademark place of work database
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Hydrogenation of isocyanates using 10% palladium-on-carbon catalyst has also been used to prepare N-alkyl formamides (3). References 1. U. Blank et al, US Patent 4,880,576 (November 14, 1989) 2. E. Bellis, US Patent 4,281,193 (July 28, 1981) 3. G. Howell, US Patent 4,125,724 (November 14, 1978) ADVANCES IN SYNTHETIC ORGANIC CHEMISTRY 24 Method for Producing Alkoxy Malonic Acid Dinitriles J. Bartek et al, US Patent 6,673,957 (January 6, 2004) Assignee: Lonsa AG Utility: Anesthetic Intermediate Patent: Reaction i- Acetonitrile, aluminum chloride, phosphorous oxychloride Experimental 1.
The crude material was purified by chromatography with EtOAc/petroleum ether,1:8, and the product isolated in 84% yield, bp = 363 C (extrapolated from GC). 1 H- and 19 F-NMR and mass spectrum data supplied. ACIDS AND DERIVATIVES 21 Derivatives R1 Ethyl n-Butyl 2-Ethylhexyl R2 Chloro Chloro Fluoro R3 Chloro Chloro Fluoro Yield (%) 93 86 87 Notes 1. When 4-methoxyaniline was substituted for 2,4-dichloro-5-fluoro-aniline, the corresponding diazonium tetrafluoroborate was not formed. 2. Replacing the catalyst in Step 2 with 5% palladium on alumina left cinnimate yields unchanged.
6 mbar in 33% yield. 2. The half cyanide, 2-cyano-2-methoxyacetamide, was also prepared as described below by the author and illustrated Eq. 14 mmol) were added to 100 ml acetonitrile containing methoxymaloamide (38 mmol), refluxed 3 hours, and cooled. Thereafter 100 ml aqueous NaHCO3 was added, the mixture extracted 5 times with 100 ml EtOAc, and the product isolated by chromatography on silica gel using hexane/EtOAc, 3:1, in 81% yield as an oil which solidified upon cooling. 1 H- and 13 C-NMR data supplied.