Nonfiction 3

Adenosine Receptors and Parkinson's Disease by Hiroshi Kase

Posted On February 25, 2017 at 6:56 am by / Comments Off on Adenosine Receptors and Parkinson's Disease by Hiroshi Kase

By Hiroshi Kase

This e-book is the 1st definitive evaluate on adenosine receptor antagonists and their program to the remedy of Parkinson's ailment. The impression of those novel non-dopamine medicines on vitro and in vivo structures truly exhibits their strength for the remedy of this debilitating disorder. This publication covers how the Parkinson's affliction antagonist drug, A2A, has been researched, built, and proven. it's a vital ebook for researchers drawn to the basal ganglia, purine biology, and Parkinson's affliction. Key beneficial properties* Discusses the invention and improvement of a singular non-dopaminomimetic agent for Parkinson's affliction* offers the 1st definitive evaluate of adenosine antagonists and their function within the therapy of Parkinson's sickness* provides a brand new mechanism of motion of adenosine A2A receptor antagonists in motor functionProposes a speculation of adenosine A2A receptor functionality within the striatum* finished review of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, body structure, pharmacology, and neurochemistry viewpoints

Show description

Read Online or Download Adenosine Receptors and Parkinson's Disease PDF

Best nonfiction_3 books

Adenosine Receptors and Parkinson's Disease

This e-book is the 1st definitive evaluate on adenosine receptor antagonists and their program to the remedy of Parkinson's affliction. The influence of those novel non-dopamine medicines on vitro and in vivo platforms sincerely exhibits their capability for the therapy of this debilitating illness. This publication covers how the Parkinson's illness antagonist drug, A2A, has been researched, built, and proven.

Extra resources for Adenosine Receptors and Parkinson's Disease

Sample text

Striatal interneurones: chemical, physiological and morphological characterization [published erratum appears in Trends Neurosci, 19(4) (1996) 143. Trends Neurosci, 18 (1995) 527-535. 26. , and Jacobson, K. , Glutamate residues in the second extracellular loop of the human A2A adenosine receptor are required for ligand recognition. Mol Pharmacol, 49 (1996) 683-691. 27. , Localization of adenosine receptor messenger RNAs in the rat eye. Exp Eye Res, 65 (1997) 595-602. 28. , Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine An receptor.

1994). , 1989). 34 TABLE I J. 7 e 17f aInhibition of radioligand binding to hInhibition of radioligand binding to CInhibition of binding to membranes aInhibition of binding to membranes eInhibition of binding membranes human adenosine receptors. fICs0 value. , 1995 membranes from rat brain, otherwise noted. membranes from rat striatum, otherwise noted. from rhesus monkey cortex. from rhesus monkey striatum. from HEK-293 cells stably transfected with recombinant The most intensively investigated class of adenosine A 1 antagonists besides the xanthines are adenine derivatives.

A. (1995). Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine. J Pharmacol Exp Ther 275,245-253. , and Danhof, M. (1996). Pharmacokinetic-haemodynamic relationshiPS of 2-chloroadenosine at adenosine A1 and A2Areceptors in vivo. BrJ PharmacoI 118, 369-377. , and Karasawa, A. (1993). Renal tubular site of action of KW-3902, a novel adenosine Al-receptor antagonist, in anesthetized rats. Jpn J Pharmacol 61, 251- 253. , and Kubo, K. (1993). Diuretic and renal protective effects of 8-(noradamantan-3-yl)-l,3-dipropylxanthine (KW-3902), a novel adenosine Al-receptor antagonist, via pertussis toxin insensitive mechanism.

Download PDF sample

Rated 4.14 of 5 – based on 19 votes